In this study, we consider a system of ODEs for a two-patch epidemiological model with various management strategies for outbreaks of two diseases: Cholera and Ebola. Optimal control theory is used on both models to minimize the cost of the strategies and the burden of the epidemic. We analyze whether the difference in disease transmission mechanisms affect the management strategies of two types of governance: one-size-fits-all management for both patches and customized management for each patch.