Objective: We examine the prevalence, treatment, and control of hypertension, dyslipidemia, and concomitant hypertension and dyslipidemia among Hispanics in four US communities. Methods: This was a cross-sectional study of Hispanics who participated in health screening programs from 2004 to 2006. We enrolled 5288 Hispanics in Miami (n=372), New York (n=254), Los Angeles (n=4073), and Houston (n=625). The main outcome measures were prevalence, treatment and control rates of hypertension, dyslipidemia, and concomitant hypertension and dyslipidemia. Results: Overall prevalence rates of hypertension, dyslipidemia, and concomitant hypertension and dyslipidemia were 37.5%, 26.6%, and 15.3%, respectively. Hypertension treatment rates ranged from 30.9% (Houston) to 68.2% (Miami) (P<.05), control was achieved in 34.7% (Los Angeles) to 47.8% (New York, P<05). Dyslipidemia treatment rates were lowest in Houston (36.5%) and highest in New York (75.3%, P<05), control rates were 62.3% (Houston) to 75.1 % (Los Angeles P<05). Dual treatment of hypertension/dyslipidemia ranged from 24.4% (Houston) to 69.4% (New York, P<05), dual control was achieved in 4.5% (Houston) to 35.3% (New York, P<05). Multivariable logistic regression analyses showed the odds of having each condition did not to differ by region, but regional differences existed for treatment and control. Conclusions: A high prevalence of hypertension, dyslipidemia, and combined hypertension and dyslipidemia and low control rates for hypertension and concomitant hypertension and dyslipidemia exist among US Hispanic adults in different communities. (Ethn Dis. 2008, 18:409-414)